Which one of the following is antimetabolite drug
5-fluorouracil (5-FU), capecitabine, floxuridine, cytarabine, gemcitabine, decitabine, and vidaza are some of the significant anticancer drugs in the antimetabolites class that work by interfering with DNA synthesis to cause cytotoxicity.
What is the major side effect of alkylating agents
Anemia, reduced blood cell counts (pancytopenia), and hair loss (alopecia) are among the most frequent side effects of alkylating agents.
What are called antimetabolites
Because of their structural similarity to natural purine or pyrimidine bases, nucleosides, or nucleotides—molecules required to carry out primary metabolic reactions—antimetabolites are a class of anticancer medications that act as analogues of normal metabolites and disrupt the normal metabolism.
What is the meaning of antimetabolites
(AN-tee-meh-TA-boh-lite) A medication that is remarkably similar to natural chemicals in a typical biochemical reaction in cells, but different enough to impair normal cellular division and function
What are antimetabolites explain with the help of an example
Other examples include antagonists of purines (azathioprine, mercaptopurine, and thioguanine) and antagonists of pyrimidine (fluorouracil and floxuridine), which interfere with bacterial metabolism but not human metabolism and are used to treat bacterial infections in humans.
How do antimetabolites work
The majority of agents are cell cycle phase specific for S phase and interfere with DNA and RNA synthesis by acting as false metabolites that are incorporated into the DNA strand or block essential enzymes, preventing DNA synthesis.
Which are examples of antimetabolites used in chemotherapy
Examples of antimetabolites include:
- (5-FU) 5-fluorouracil
- (6-MP) 6-mercaptopurine
- (Xeloda) Capecitabine
- Ara-Cs Cytarabine
What are cytotoxic effects
Once inside the body, they can cause a variety of bioeffects like apoptosis, cell membrane disruption, inflammation, and oxidative stress. These include spontaneous protein adsorption, interaction with cell membranes, DNA, lipids, and proteins.
How do antimetabolites exert their cytotoxic effect
Some of the important drugs from this class include 5-fluorouracil (5-FU), capecitabine, floxuridine, cytarabine, gemcitabine, decitabine, and vidaza. Antimetabolites are a group of anticancer agents that interfere with DNA synthesis to produce their cytotoxic effects.
What are the adverse effects of methotrexate
Methotrexate may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- swollen and soft gums.
- reduced appetite
- eye redness.
- hair fall
Which antibiotics are antimetabolites
Each monomer unit of DNA and RNA contains either a purine or a pyrimidine as the base, and the most frequently used antimetabolites are methotrexate, trimethoprim, and sulfonamides, which inhibit the synthesis of dTMP, which is a pyrimidine (Sect.
In which phase of the cell cycle do most antimetabolites affect cells
Because they act primarily on cells synthesizing new DNA for the formation of new cells, antimetabolites are most effective during the S-phase of cell division. The toxicities associated with these drugs are seen in cells that are growing and dividing quickly.
Which chemotherapy drug has heart failure as a serious toxicity
The widely used chemotherapy drug doxorubicin may cause heart toxicity, which could result in congestive heart failure, according to recent research.
Which term is used for antimetabolite block the metabolic action of Vitamin causing its deficiency
What is toxic mucositis
Myoo-koh-SY-tis is a side effect of some cancer treatments in which the lining of the digestive system becomes inflamed, frequently manifesting as mouth sores.
How does methotrexate make you feel
Up to one-third of rheumatoid arthritis (RA) patients who take methotrexate experience mouth ulcers or sores, and the majority experience GI issues like nausea and vomiting. Other common side effects include headaches, fatigue, and a general feeling of being “blah.”
Are antimetabolites steroids
Methotrexate has been shown to be effective in remitting and persistent disease, as well as in ocular, 234, 288 cutaneous, 289 – 291 sinus, 292, and neurologic disease. Methotrexate is a commonly used steroid-sparing cytotoxic agent for sarcoidosis.
What are antimetabolite immunosuppressant drugs
An inosine monophosphate dehydrogenase inhibitor used to prevent the rejection of kidney, heart, or liver transplants. An immunosuppressant used to prevent organ transplant rejections.